The present invention provides stable pre-fusion respiratory syncitial virus (RSV) F polypeptides, immunogenic compositions comprising said polypeptides and uses thereof for the prevention and/or treatment of RSV infection.本發明提供了穩定的融合前呼吸系融合細胞病毒(RSV)F多肽、包含所述多肽之免疫原性組合物及其用於RSV感染的預防和/或治療之用途。