This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.本發明係關於對抗動物之體外寄生蟲及體內寄生蟲的局部組合物,其包含至少一種異唑啉活性劑及醫藥學上可接受之載劑,視情況與一或多種其他活性劑組合。本發明亦提供一種根除、控制及預防動物之寄生蟲感染及侵染的改良方法,其包括向有需要之動物投與本發明組合物。