PROCEDE DE TRAITEMENT OU D'AMELIORATION DE TROUBLES METABOLIQUES A L'AIDE D'AGONISTES DU RECEPTEUR DU GLP-1 CONJUGUES A DES ANTAGONISTES DU RECEPTEUR DU PEPTIDE INHIBITEUR GASTRIQUE (GIPR)
CHENG, YUAN,NETIROJJANAKUL, CHAWITA,HOLDER, JERRY RYAN,WU, BIN,FALSEY, JAMES R.,HERBERICH, BRADLEY J.,SHAM, KELVIN,MIRANDA, LESLIE P.,LU, SHU-CHEN,VENIANT-ELLISON, MURIELLE M.,STANISLAUS, SHANAKA,YIE,
申请号：
CA3049023
公开号：
CA3049023A1
申请日:
2018.01.16
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for the GIPR polypeptide conjugated to a GLP-1 receptor agonist are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises an antibody or functional fragment thereof comprising a cysteine at one or more conjugation site(s) wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue.
