A compound of Formula Iin free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10and R11have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.式I化合物呈自由態或鹽或溶劑合物形式，其中R1,R2,R3,R4,R5,R6,R7,R8,R9,R10及R11均具有如本專利說明書中所指示之意義，其可用於治療對上皮鈉通道之阻抑有回應之疾病。亦描述含有該化合物之醫藥組合物及製備該化合物之方法。
