經取代之四氫哌喃及使用方法农业专利-农业学术服务平台

发明人:: KYM, PHILIP R.,金　飞利浦Ｒ,金　飛利浦Ｒ,WANG, XUEQING,王学庆,王學慶,SEARLE, XENIA B.,希尔　辛那Ｂ,希爾　辛那Ｂ,LIU, BO,刘波,劉波,YEUNG, MING C.,杨　铭,楊　銘,金飞利浦R,金飛利浦R,希尔辛那B,希爾辛那B,杨铭,楊銘

摘要：: Compounds of formula (I) and pharmaceutically acceptable salts or radiolabelled forms thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and m are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.一種式(I)化合物，及其醫藥上可接受之鹽或經放射性標記形式，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12及m係如說明書中所定義，其可用於治療藉由囊性纖維化跨膜傳導調節(Cystic Fibrosis Transmembrane Conductance Regulator；CFTR)蛋白預防或改善之病狀或病症。本發明闡述製備該等化合物之方法，亦闡述式(I)化合物之醫藥組合物及使用該等化合物及組合物之方法。