經取代之烷及其使用方法农业专利-农业学术服务平台

发明人:: KYM, PHILIP R.,金　飞利浦Ｒ,金　飛利浦Ｒ,WANG, XUEQING,王学庆,王學慶,SEARLE, XENIA B.,希尔　辛那Ｂ,希爾　辛那Ｂ,LIU, BO,刘波,劉波,YEUNG, MING C.,杨　铭,楊　銘,ALTENBACH, ROBERT J.,爱登贝奇　罗伯特Ｊ,愛登貝奇　羅伯特Ｊ,VOIGHT, ERIC,沃特　艾瑞克,BOGDAN, ANDRE,金飞利浦R,金飛利浦R,希尔辛那B,希爾辛那B,杨铭,楊銘,爱登贝奇罗伯特J,愛登貝奇羅伯特J,沃特艾瑞克

摘要：: The invention provides for compounds of formula (I) wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R" have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).本發明提供式(I)化合物，其中R1、X、Y、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13、R14、m及R"具有本說明書中定義之任一值，及其醫藥學上可接受之鹽，其適用作治療由CFTR介導及調節之疾病及病狀的藥劑，該等疾病及病狀包括囊腫纖維化症、休格連氏症候群、胰臟功能不全、慢性阻塞性肺病及慢性阻塞性呼吸道疾病。亦提供醫藥組合物，其包含一或多種式(I)化合物。