The present application provides a compound of formula I:(I), or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein R1-R10, m, n, p, andare as described herein. The present invention relates generally to FXR modulators and to methods of making and using said compounds.本案提供一種式I化合物(I), 或其醫藥上可接受之鹽、溶劑合物或胺基酸軛合物,其中R1-R10、m、n、p及係如本文中描述。本發明大致上係有關於FXR調節劑及該等化合物之製造方法及使用方法。