V. VIJAYA BASKAR,SRIRIPRAGADA MAHENDER RAO,P. VINOD KANNAN,D. SAM DANIEL PRABHU
申请号：
IN1110/CHE/2005
公开号：
IN257127B
申请日:
2005.08.11
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
The present invention relates to an improved process for the preparation of compound of formula (I), 8-chloro-6,11 -dihydro-11 -(4-piperidinylidene)-5H-benzo[5 56]cyclohepta[ 1,2-b]pyridine (Desloratadine) or its pharmaceutically acceptable salts thereof, by reacting a compound of formula (II), 4-(8-Chloro-5,6-dihydro-llH-benzo[5,6]cyclohepta[l,2-b]pyridin-ll-ylidene)-l piperidinecarboxylic acid ethyl ester (Loratadine) with sodium hydroxide in a solvent mixture of toluene and polyethylene glycol (PEG 400) at reflux temperature.
