ФАРМАЦЕВТИЧЕСКИЕ ПРЕПАРАТЫ АЗОЛОВ ДЛЯ ПАРЕНТЕРАЛЬНОГО ВВЕДЕНИЯ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, ЧУВСТВИТЕЛЬНЫХ К АЗОЛЬНЫМ СОЕДИНЕНИЯМ
БОРД ОФ РИДЖЕНТС; ДЗЕ ЮНИВЕРСИТИ ОФ ТЕХАС СИСТЕМ (US)
发明人:
АНДЕРССОН Борхе С. (US),ТАРРАНД Джеффри (US),ВАЛЬДЕС Бениньо К. (US)
申请号：
RU2013132703/15
公开号：
RU2013132703A
申请日:
2011.12.16
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1 A pharmaceutical composition suitable for parenteral administration comprising azole pharmaceutical agent and a first solvent, said first solvent comprises a) an alcohol selected from benzyl alcohol and / or the acidified ethanol and b) polyethylene glycol (PEG), wherein the azole agent is dissolved in said first solvent, wherein the composition is substantially free of nonionic surfactants and containing less than 5% vody.2. A composition according to claim 1, wherein said first solvent contains both ethanol and benzyl spirt.3. A composition according to claim 1, wherein the first solvent comprises an acidified etanol.4. A composition according to claim 3, wherein the acidified ethanol additionally determined as a combination of ethanol and the acid and the first solvent has a pH from about 1 to about 5.5. A composition according to claim 4, wherein the first solvent has a pH of from about 3 to about 4.6. A composition according to claim 4, wherein the acid is HCl, citric acid, acetic acid or glutamic kislota.7. A composition according to claim 1, wherein the ratio of PEG to alcohol is from 27 to 2.8. A composition according to claim 7, wherein the ratio of PEG to alcohol is from 12 to 8.9. A composition according to claim 1, wherein said PEG is selected from the group consisting of PEG-100, PEG-200, PEG-300, PEG-400 and PEG-800.10. A composition according to claim 9, wherein the polyethylene glycol is PEG-400.11. A composition according to claim 1, wherein the first solvent comprises from 10% to 90% (vol. / vol.) PEG.12. A composition according to claim 11, wherein the first solvent comprises from 30% to 90% (vol. / vol.) PEG.13. A composition according to claim 1, wherein the first solvent comprises from 40% to 80% (vol. / vol.) PEG.14. A composition according to claim 1, wherein the alcohol1, Фармацевтическая композиция, подходящая для парентерального введения, содержащая азольное фармацевтическое средство и первый растворитель, при этом указанный первый раств
