Georg Jaeschke;Bernd Buettelmann;Sabine Kolczewski;Paul Spurr;Simona Maria Ceccarelli;Eric Vieira;Richard Hugh Philip Porter
发明人:
Bernd Buettelmann,Simona Maria Ceccarelli,Georg Jaeschke,Sabine Kolczewski,Richard Hugh Philip Porter,Paul Spurr,Eric Vieira
申请号：
US12613089
公开号：
US08293916B2
申请日:
2009.11.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to diazole derivatives of the general formulawherein A, E, R1, R2 and R3 are as defined in application and pharmaceutical compositions containing them. The invention also relates to use of such compounds for the treatment of diseases mediated by the metabotropic glutamate receptors (mGluR), such as anxiety, chronic and acute pain, protection against liver damage, urinary incontinence, obesity, Fragile-X and autism, Alzheimer's disease, epilepsy, schizophrenia, ischemia, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia caused by AIDs, and Parkinson's disease.
