KURIMOTO, AYUMU,HASHIMOTO, KAZUKI,ISOBE, YOSHIAKI,BROUGH, STEPHEN,MILLICHIP, IAN,WADA, HIROKI,BONNERT, ROGER,MCINALLY, THOMAS
申请号：
CA2559036
公开号：
CA2559036C
申请日:
2005.03.24
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides an 8-oxoadenine compound havingimmunemodulating activities such as an interferon inducing activity anduseful as an antiviral agent and antiallergic agent, which is represented bythe following formula (1):(see formula 1)[wherein the ring A represents a 6-10 membered aromatic carbocyclic ringand the like, R represents a halogen atom, an alkyl group and the like, nrepresents an integer of 0-2, Z1 represents alkylene, X 2 representsoxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1,Y2 and Y3 represent independently a single bond or an alkylene group,X1represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or analkyl group) or a single bond, R2 represents a substituted or unsubstitutedalkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group,an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.
