FIELD: chemistry.SUBSTANCE: invention relates to the field of organic chemistry, specifically to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein each R1 and R1a is independently selected from the group consisting of H, methyl, CONHC(CH3)3, OH, CO2H, CO2CH3, CO2CH2CH3, CH2OH, CN, OCH3 and phenyl； or R1 represents CH2CO2H； or any two R1 on the same carbon atom when taken together may form a group of the formula =O； Ar is a heteroaryl group selected from the group consisting of:,where each R7 is independently selected from the group consisting of halogen, OH, CN, C1-C3 alkyl, C1-C3 alkoxy, C3cycloalkyl, heterocycloalkyl selected from piperidine which may be substituted with one carboxyl group； C6aryl, which may be substituted by one halogen atom； heteroaryl, selected from the group consisting of thiophene, furan, which may be substituted with C1-C3alkyl, and pyridine； wherein R8 is selected from the group consisting of H, C1-C2alkyl, C1alkoxy, C3cycloalkyl and SO2R9； wherein R9 is C6aryl； e is an integer selected from a group consisting of 0, 1 and 2； f is an integer selected from a group consisting of 0 and 1； A is -CRaRb-； B is CH2； wherein each Ra and Rb is independently selected from the group consisting of H, OH, CN, CF3, C1-C3alkyl, C6aryl, heteroaryl selected from thiophene； and wherein Ra and Rb are different； W1 and W2 are selected such that one is N and the other is (CR12)； bond from the carbonyl carbon is joined to W1 or W2, which is N； D is O or (CR12)； a is an integer selected from a group consisting of 0, 1 and 2； b is an integer selected from a group consisting of 0 and 1； c is equal to 1. Invention also relates to the pharmaceutical composition based on compound with formula (I) and use of compound with formula (I). .EFFECT: novel heterocyclic compounds having the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).12 cl, 1 tbl, 268 exИзобретение относится к области органической химии, а
