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PHARMACEUTICAL COMPOSITION AND ITS INTRODUCTION
专利权人:
ВЕРТЕКС ФАРМАСЬЮТИКАЛЗ ИНКОРПОРЕЙТЕД (US)
发明人:
ДОКОУ Элени (US),ДЖАМЗАД Шахла (US),ДАС Лаура (US),ИСРАНИ Мегхна Джай (US),КНЕЗИЧ Драгутин (US),КУЗМИССИОН Эндрю Г. (US)
申请号:
RU2013113627/15
公开号:
RU2013113627A
申请日:
2011.08.26
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A pharmaceutical composition comprising a solid dispersion of amorphous or substantially amorphous Compound 1, a filler, a sweetener, a disintegrant, a glidant, a lubricant, and optionally a moisturizer. The pharmaceutical composition according to claim 1, wherein the pharmaceutical composition comprises from about 30 to about 50% solid dispersion by weight of the composition. The pharmaceutical composition of claim 2, wherein the pharmaceutical composition comprises about 35% of a solid dispersion by weight of the composition. The pharmaceutical composition of claim 2, wherein the pharmaceutical composition comprises about 47% of a solid dispersion by weight of the composition. The pharmaceutical composition of claim 2, wherein the pharmaceutical composition comprises about 46.9% of a solid dispersion by weight of the composition. The pharmaceutical composition of claim 1, wherein the excipient comprises: mannitol, lactose, sucrose, dextrose, maltodextrin, sorbitol, xylitol, powdered cellulose, polyhydric alcohols, microcrystalline cellulose, silicified microcrystalline cellulose, cellulose acetate, methylcellulose cellulose cellulose cellulose cellulose cellulose cellulose cellulose cellulose cellulose cellulose cellulose cellulose cellulose acetate. , starch, pre-gelatinized starch, calcium hydroorthophosphate, calcium sulfate, calcium carbonate, or a combination thereof. 7. The pharmaceutical composition of claim 1, wherein the excipient comprises mannitol in an amount of from about 30 to about 80% by weight of the composition. The pharmaceutical composition of claim 7, wherein the excipient comprises mannitol in an amount of from about 42 to about 57.5% by weight of the composition. The pharmaceutical composition of claim 1, wherein the sweetener includes: glucose, sugar1. Фармацевтическая композиция, включающая в себя твердую дисперсию аморфного или, по существу, аморфного Соединения 1, наполнитель, подслащивающее вещество, дезинтегрирующее средство, скольз
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