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LABORATIVE COMPOSITIONS AND METHODS OF TREATMENT OF CONSTIPATION AND RELATED GASTROINTESTINAL DISEASES AND CONDITION
专利权人:
ИНК. (US);САЛИКС ФАРМАСЬЮТИКАЛЗ
发明人:
БОРОДИ Томас Джулиус (AU)
申请号:
RU2015111258
公开号:
RU2015111258A
申请日:
2013.08.29
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. Composition made for delayed release containing bisoxatin (or 2,2-bis (4-hydroxyphenyl) -2H-benzo [b] [1,4] oxazin-3 (4H) -one) or bisoxatin acetate, and enteric coating. 2. The composition of claim 1, wherein the enteric coating comprises a gastric juice resistant coating that dissolves at pH 7 in the terminal ileum. A composition according to claim 1, wherein the enteric coating comprises poly (meth) acrylate, methyl methacrylate and / or methacrylic acid ester. The composition of claim 1, wherein the enteric coating comprises vinyl or polyvinyl acetate phthalate; hydroxypropyl methylcellulose (HPMC), high viscosity HPMC; Ultra-high viscosity receiver array; polyvinylpyrrolidone (PVP); PVP-K90; cellulose, microcrystalline cellulose (MCC), methyl cellulose, hydroxymethyl cellulose, ethyl cellulose and a copolymer of ethyl acrylate, methyl methacrylate and methacrylic acid with quaternary ammonium groups; or any combination or mixture thereof. 5. The composition of claim 1, wherein the enteric coating comprises: cellulose acetate phthalate, hydroxypropyl methyl cellulose phthalate, polyvinyl acetate phthalate, hydroxypropyl methyl cellulose acetate succinate, cellulose trimellate acetate, cellulose acetate, hydroxypropyl methyl cellulose acetate acetate cellulose acetate cellulose butyrate, cellulose acetate propionate, methyl methacrylic acid-methyl methacrylate copolymer, methyl acrylate copolymer, methyl methacryl and that of methacrylic acid, a copolymer of methyl vinyl ether and maleic anhydride, ethyl acrylate and1. Композиция, изготовленная для отсроченного высвобождения, содержащая бисоксатин (или 2,2-бис(4-гидроксифенил)-2Н-бензо[b][1,4]оксазин-3(4Н)-он) или бисоксатина ацетат, и энтеросолюбильное покрытие.2. Композиция по п. 1, в которой энтеросолюбильное покрытие содержит резистентное к желудочному соку покрытие, которое растворяется при рН 7 в терминальном отделе подвздошной кишки.3. Композиция по п. 1, в которой энтеросолюбильное покрытие содержит по
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