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A NEW ETHER OF ACETIC ACID OR ITS SALT
专利权人:
ТАЙХО ФАРМАСЬЮТИКАЛ КО.; ЛТД. (JP)
发明人:
НАНРИ Масато (JP),ИВАСАВА Йосикадзу (JP),САКАКИБАРА Фукумицу (JP),АОКИ Синити (JP)
申请号:
RU2014135417
公开号:
RU2014135417A
申请日:
2013.01.25
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. An ester of acetic acid represented by the following formula or a salt thereof: wherein R is an optionally substituted deuterated lower alkyl. 2. The acetic acid ester of claim 1, or a salt thereof, wherein R is a linear chain deuterated C-alkyl. 3. The ester of acetic acid according to claim 1 or 2, or a salt thereof, where R is n-propyl, in which 2-7 hydrogen atoms are replaced by deuterium. 4. Acetic acid ester according to any one of paragraphs. 1 and 2, or a salt thereof, where R is propyl-2,2,3,3,3-d5, propyl-1,1,2,2,3,3,3-d7, propyl-1,1-d2 , propyl-2,2-d2, propyl-3,3,3-d3 or propyl-1,1,2,2-d4.5. Acetic acid ester selected from the following compounds (a) to (f), or a salt thereof: (a) 4-piperidinyl-2,2-diphenyl-2- (propoxy-2,2,3,3,3-d5) acetate, (b) 4-piperidinyl-2,2-diphenyl-2- (propoxy-1,1,2,2,3,3,3-d7) acetate, (c) 4-piperidinyl-2,2-diphenyl -2- (propoxy-1,1-d2) acetate, (d) 4-piperidinyl-2,2-diphenyl-2- (propoxy-2,2-d2) acetate, (e) 4-piperidinyl-2,2 diphenyl-2- (propoxy-3,3,3-d3) acetate, and (f) 4-piperidinyl-2,2-diphenyl-2- (propoxy-1,1,2,2-d4) acetate. 6 . A pharmaceutical composition comprising an effective amount of an acetic acid ester according to any one of claims. 1-5, or its salts, and a pharmaceutical carrier. 7. A prophylactic and / or therapeutic agent for a disease, the intensity of which should be reduced by increasing intraurethral pressure, an agent containing an effective amount of an acetic acid ester according to any one of claims. 1-5, or its salts, and a pharmaceutical carrier. 8. A prophylactic and / or therapeutic anti-stress urinary incontinence agent, an agent containing an effective amount of an acetic acid ester according to any one of claims. 1-5, or its salts, and a pharmaceutical carrier. 9. A method for preventing and / or treating a disease, the intensity of which is believed to be reduced by increasing intraurethral pressure, a method comprising administering effective amounts1. Эфир уксусной кислоты, представленный с
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