RESHETNIKOV VIKTOR IVANOVICH,Решетников Виктор Иванович,KAZJANIN ALEKSANDR VIKTOROVICH,Казьянин Александр Викторович,EFIMOVA NINA PAVLOVNA,Ефимова Нина Павловна,KAMENEVA MARGARITA ALEKSEEVNA,Каменева
申请号：
RU2002117099/15
公开号：
RU0002241446C9
申请日:
2002.06.27
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: medicine, pharmacology.SUBSTANCE: invention refers to medicine and pharmaceutical industry, and concerns preparing dosage forms of bacteriophages. The pharmaceutical composition contains bacteriophages with an excipient in the form of dosage form and additionally contains water-soluble polymers and sugars the water-soluble polymers are presented by cellulose derivatives, or low- or medium-molecular polyvinyl pyrrolidones, or polyethylene glycols having molecular weight 4,000 or 6,000, or sodium alginate while the sugars are lactose and (or) mannitol the cellulose derivatives are carboxymethyl cellulose sodium salt, or oxypropylmethyl cellulose, or oxypropyl cellulose the pharmaceutical composition contains the substances in the following proportions, wt %: bacteriophage with Appelmans titre not less than 10-4 calcium carbonate - 70.0-85.0 lactose and (or) mannitol - 5.0-15.0 sodium carboxymethyl cellulose - 0.1-1.0 microcrystalline cellulose - 2.0-8.0 carboxymethyl starch - 1.0-4.0 magnesium or calcium stearate - 0.25-1.0 the pharmaceutical composition can be presented in the form of tablets of 0.1 g with a gastro-resistant coating. What is declared is a method for preparing the above composition, wherein a drying process is preceded by introducing synthetic water-soluble polymers into a phagolysate with introducing sugars into the excipient or phagolysate, and the drying process performed in vacuum to humidity 1-2%.EFFECT: invention provides higher stability of the composition.4 clИзобретение относится к медицине и фармацевтической промышленности и касается изготовления лекарственных форм бактериофагов. Фармацевтическая композиция содержит бактериофаги с наполнителем в виде дозированных лекарственных форм и дополнительно содержит водорастворимые полимеры и сахара, при этом в качестве водорастворимых полимеров использованы производные целлюлозы, или поливинилпирролидоны низко- или среднемолекулярные, или полиэтиленгликоли с молекулярной массой 4000 или 6000,
