Relating to compounds of formula (i), where the - 2 is a bicyclic heteroaryl optionally substituted the formula (a), where indicates the binding site of A2 and A4 indicates 12 or 3 optional substituents, which may be selected independently: halogno, cyano, optionally substituted alkyl, alkoxy optionally substituted,And a carboxyl Group x1 is c, N, s or c or N x2, X3 is c, N, s or u, and X4 is CN or s under the condition of 1 to 3 heteroatoms x are present r1 is Hydrogen or optionally substituted alkyl aryl substituted CYCL is,Heteroaryl substituted or non substituted Q is Hydrogen or c1-c4 alkyl,They can form a Ring of 5 or 6 members condensates with CYCL n is an integer of 0 OR 1 to 8 is alcanodiilo optionally substituted A1 A2 is alcanodiilo optionally substituted or enlACE Live R3 is Hydrogen or alkyl, optionally substituted y2 is c o n.These compounds are inhibitors of Ferroportin, the inhibition of Transport of Iron,Used as a drug in the prophylaxis and \/ or treatment of diseases caused by a lack of hepcidin and Iron Metabolism disorders.Such as States of iron overload in thalassemia and Hemochromatosis.Referido a compuestos de Formula (A-I), en donde Het-2 es un heteroarilo biciclico opcionalmente sustituido de la formula (a) en donde indica el sitio de union a A2 y R4 indica 1, 2 o 3 sustituyentes opcionales, que se pueden seleccionar, de forma independiente entre: halogno, ciano, alquilo opcionalmente sustituido, alcoxi opcionalmente sustituido, y un grupo carboxilo X1 es C, N, S u O X2 es C o N X3 es C, N, S u O y X4 es C, N o S con la condicion de que 1 a 3 heteroatomos X esten presentes R1 es hidrogeno o alquilo opcionalmente sustituido Cycl es arilo sustituido, heteroarilo sustituido o no sustituido Q es hidrogeno o alquilo C1-C4, que pueden formar un anillo de 5 o 6 miembros condensados con Cycl n es 0 o un numero entero de 1 a 8 A1 es alcanodiilo opcionalmente sustituido A2 es alcanodiilo opcionalmente sustituido o un enlace directo R3 es hidrogeno o
