Luke Green;Thomas Luebbers;Andrew Thomas;Anja Limberg;Karlheinz Baumann
发明人:
Karlheinz Baumann,Luke Green,Anja Limberg,Thomas Luebbers,Andrew Thomas
申请号：
US13405404
公开号：
US08703763B2
申请日:
2012.02.27
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to compounds of formula Ihetaryl I, hetaryl II, R1, R2, R3, Y,m, and o or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
