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MODULATORS FOR AMYLOID BETA
专利权人:
Erwin Goetschi
发明人:
Erwin Goetschi,Synese Jolidon,Thomas Luebbers
申请号:
US13437057
公开号:
US20120190682A1
申请日:
2012.04.02
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention relates to compounds of formulawherein R1, R2, R3, R4, and Ar are as defined in the specification and claims, or to pharmaceutically active acid addition salts of such compounds. Compounds of formula I are modulators for amyloid beta and may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimers disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
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