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beta amyloid modulators
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
ERWIN GOETSCHI,SYNESE JOLIDON,THOMAS LUEBBERS
申请号:
BRPI0920651
公开号:
BRPI0920651A2
申请日:
2009.09.29
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
The invention relates to compounds of formula wherein R1, R2, R3, R4, and Ar are as defined in the specification and claims, or to pharmaceutically active acid addition salts of such compounds. Compounds of formula I are modulators for amyloid beta and may be useful for the treatment or prevention of a disease associated with the deposition of &bgr;-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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