The present study of designing and development of polyherbal and metallic bhasmas formulations for the Antiretroviral activity is totally new and Innovative Invention. The present study is based on the evidences, proofs obtained by the Ayurvedic, Alternative medicine, folk remedy and Tribal medical practices. List of herbal medicinal plants, natural sources such as metallic bhasmas(Ash), honey, Navneet (ghee) as bases are used and list of the same is enclosed. The product designed by the applicants is claimed to be powerful Immuno-modulating agents which successfully employed for the treatments of HIV and AIDS and also other related diseases. All clinical, biochemistry, pathological laboratory documents have been recorded and documented.