DISEASESAND DISORDERS cc kr) ,• "% h N SD (R ), 0 1-1 O C RA N H R 7 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIPO I PCT oimitia °nolo OilIIIII0111IIIIIOH o imio oimIE (10) International Publication Number WO 2018/166528 Al (51) International Patent Classification: CO7D 403/04 (2006.01) A61K 31/445 (2006.01) CO7D 403/14 (2006.01) A61K 31/506 (2006.01) A61K 31/4545 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/CN2018/079292 (22) International Filing Date: 16 March 2018 (16.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2017/077059 17 March 2017 (17.03.2017) CN (71) Applicants: GENENTECH, INC. [US/US]； 1 DNA Way, South San Francisco, California 94080 (US). THE RE- GENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]； 1111 Franklin Street, Twelfth Floor, Oakland, California 94607 (US). = (72) Inventors； and (71) Applicants (for MN only): BRAUN, Marie-Gabrielle [FR/US]； 1 DNA Way, South San Francisco, California 94080 (US). GIBBONS, Paul [US/US]； 1 DNA Way, South San Francisco, California 94080 (US). LEE, Wendy [US/US]； 1 DNA Way, South San Francisco, California 94080 (US). LY, Cuong [US/US]； 1 DNA Way, South San Francisco, California 94080 (US). RUDOLPH, Joachim [DE/US]； 1 DNA Way, South San Francisco, California 94080 (US). SCHWARZ, Jacob [US/US]； 1 DNA Way, South San Francisco, California 94080 (US). ASHKE- NAZI, Avi [US/US]； 1 DNA Way, South San Francisco, California 94080 (US). FU, Leo [CN/CN]； 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131 (CN). LAI, Tommy [CN/CN]； 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131 (CN). WANG, Fei [CN/CN]； 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131 (CN). BEVERIDGE, Ramsay [CA/CA]； 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1
