International Patent Classification: CO7D 487/04 (2006.01) A61K 31/41 (2006.01) CO7D 498/04 (2006.01) A61K 31/437 (2006.01) A61P 25/16 (2006.01) A61K 31/5365 (2006.01) A61P 25/28 (2006.01) (21) International Application Number: PCT/EP2018/068998 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) vitivio VIII oviolo Ho Nom n111110 vimiE (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/012063 Al (43) International Publication Date 17 January 2019 (17.01.2019) WIPO I PCT (22) International Filing Date: Published: with international search report (Art 21(3)) 12 July 2018 (12.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/532,767 14 July 2017 (14.07.2017) US (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]； Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant (for US only): GENENTECH, INC. [US/US]； 1 DNA Way, South San Francisco, California 94080 (US). (72) Inventors: PATEL, Snahel； c/o Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080 (US). HAMILTON, Gregory； c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). ZHAO, Guiling； c/o Genentech, Inc., 1 DNA Way, South San Francisco, Cal- ifornia 94080 (US). CHEN, Huifen； c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). DANIELS, Blake； c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). STIVALA, Craig； c/o Genentech, Inc., 1 DNA Way, South San Francisco, Cal- ifornia 94080 (US). (74) Agent: SAUER, Frank； Grenzacherstrasse 124,
