INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT (51) International Patent Classification: C07K 16/18 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: PCT/US2018/024300 (22) International Filing Date: ill 1111u°11111VIIIVIIII o monii mina° oimIE (10) International Publication Number WO 2018/183175 Al (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/477,535 62/532,696 62/577,559 62/580,359 26 March 2018 (26.03.2018) English English 28 March 2017 (28.03.2017) US 14 July 2017 (14.07.2017) US 26 October 2017 (26.10.2017) US 01 November 2017 (01.11.2017) US (71) Applicant: GENENTECH, INC. [US/US]； 1 DNA Way, South San Francisco, California 94080 (US). (72) Inventors: KERCHNER, Geoffrey； c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). TENG, Edmond； c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). (74) Agent: SCARR, Rebecca B. et al.； 500 W. Silver Spring Drive, Suite K-200, Glendale, Wisconsin 53217 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), Europ
