a 600 • -•500 .-! DOX 0 1 2 3 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT Hu onus °nolo olomonliomioluo ow (10) International Publication Number WO 2018/140729 Al (51) International Patent Classification: A61K 39/00 (2006.01) C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/015452 (22) International Filing Date: 26 January 2018 (26.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/451,603 27 January 2017 (27.01.2017) US (71) Applicant: NGM BIOPHARMACEUTICALS, INC. [US/US]； 333 Oyster Point Blvd, South San Francisco, CA 94080 (US). (72) Inventors: SHEN, Wenyan； 333 Oyster Point Blvd, South San Francisco, CA 94080 (US). WANG, Yan； 333 Oys- ter Point Blvd, South San Francisco, CA 94080 (US). MATERN, Hugo； 333 Oyster Point Blvd, South San Fran- cisco, CA 94080 (US). LIU, Zhonghao； 333 Oyster Point Blvd, South San Francisco, CA 94080 (US). (74) Agent: WEISSER, Tamera, M. et al.； Jones Day, 250 Vesey Street, New York, NY 10281-1047 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM
