isolated nucleic acid sequence, t-cell, vector, and persistent t-cell population

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

CARL H. JUNE,JOHN SCHOLLER,MATTHEW J. FRIGAULT,YANGBING ZHAO

申请号：

BR112014020499

公开号：

BR112014020499A2

申请日:

2013.02.22

申请国别(地区):

BR

年份:

2019

代理人:

摘要：

The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/