Matthew J. Frigault,Yangbing Zhao,John Scholler,Carl H. June
申请号：
US14375015
公开号：
US10040846B2
申请日:
2013.02.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.
