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Compositions and methods for generating a persisting population of T cells useful for the treatment of cancer
专利权人:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人:
Matthew J. Frigault,Yangbing Zhao,John Scholler,Carl H. June
申请号:
US14375015
公开号:
US10040846B2
申请日:
2013.02.22
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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