FRIGAULT, MATTHEW J.,ZHAO, YANGBING,SCHOLLER, JOHN,JUNE, CARL, H.
申请号：
EP13751162
公开号：
EP2817318A4
申请日:
2013.02.22
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.
