Frigault, Matthew J.,Zhao, Yangbing,Scholler, John,June, Carl H.
申请号：
AU2013222267
公开号：
AU2013222267A1
申请日:
2013.02.22
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.
