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Combination therapy of TLR7 and VHb with capaids assembly inhibitors
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
DAI, Lue,GAO, Lu
申请号:
PE2017001480
公开号:
PE20171648A1
申请日:
2016.03.15
申请国别(地区):
PE
年份:
2017
代理人:
摘要:
The utility model relates to a pharmacological component, which comprises a methanol 7 (TLR7) formula or a class II receptor promoter, wherein: R1 is hydroxyl, C1-C6 tar, etc.; R2 is hydrogen, C1-C6 tar, etc.; R3 is hydrogen, C1-C6 is carbon tar; R4 and R5 are hydrogen, halogen C2-C6 or C1-C6 tar; R6 and R7 are hydrogen, hydrocarbon, C1-C6 is carbon. C1-C6, among others; R8 is a C1-C6 carbide or hydrocarbon; a drug resistance of VHb III, wherein R9 is a C1-C6 tar; R10 is an alternative phenyl; R11 is a hydrogen or C1-C6 tar; R12 is a monocyclic isopropene, and so on;And a pharmaceutically acceptable car He also mentioned a manufacturing method and a treatment pack. This ingredient is useful in the treatment of hepatitis B infection.Referida a una composicion farmaceutica que comprende un agonista de los receptores de tipo Toll 7 (TLR7) de formula I o II, donde: R1 es hidroxi, alquilo C1-C6, entre otros; R2 es hidrogeno, alquilo C1-C6, entre otros; R3 es hidrogeno o alquil C1-C6 carbonilo; R4 y R5 son hidrogeno, alquenilo C2-C6 o alquilo C1-C6; R6 y R7 son hidrogeno, alquilo C1-C6, entre otros; R8 son hidrogeno o alquil C1-C6 carbonilo; un inhibidor del ensamblaje de la capsida del VHB de formula III, donde: R9 es alquilo C1-C6; R10 es fenilo sustituido; R11 es hidrogeno o alquilo C1-C6; R12 es un heterociclilo monociclico, entre otros; y un vehiculo farmaceuticamente aceptable. Tambien se refiere a un metodo de fabricacion y a un kit de tratamiento. Dicha composicion es util en el tratamiento de la infeccion por el virus de la hepatitis B.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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