Refers to a compound of formula (i), wherein R1 is a heteroaryl Ring R2 is selected from h, alkyl of C1 - C6, among others R3 is choosing phenyl piridilo, N is 0 to 3 J is a ring cycloalkyl, aryl ring, among others.Preferred compounds are (R) - 6 - ((3 - 6 - cloropiridin - il) sulfonyl) - 1 - (4-fluorophenyl) - 4,4, - hexahidro 5,6,7,8 - 1H pyrazolo [3,4] - G isoquinolin IL - 4 - (pyridin-2-yl) methanone (R) () - 6 - ((3 - 6 - cloropiridin - il) sulfonyl) - 1 - (4-fluorophenyl) - 4,4, - hexahidro 5,6,7,8 - 1H pyrazolo [3,4] isoquinolin - G - 4 - 2 (IL -) thiazole - il) methanone, among others. It also relates to a Pharmaceutical composition.These compounds are useful as modulators of the glucocorticoid receptor.SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE R1 ES UN ANILLO DE HETEROARILO R2 SE SELECCIONA DE H, ALQUILO C1-C6, ENTRE OTROS R3 SE SELCCIONA DE FENILO Y PIRIDILO, n ES 0-3 J ES UN ANILLO CICLOALQUILO, ANILLO DE ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (R)-(6-((6-CLOROPIRIDIN-3-IL)SULFONIL)-1-(4-FLUOROFENIL)-4,4 a, 5,6,7,8-HEXAHIDRO-1H-PIRAZOLO[3,4-g]ISOQUINOLIN-4 a- IL)(PIRIDIN-2-IL)METANONA (R)-(6-((6-CLOROPIRIDIN-3-IL)SULFONIL)-1-(4-FLUOROFENIL)-4,4 a, 5,6,7,8-HEXAHIDRO-1H-PIRAZOLO[3,4-g]ISOQUINOLIN-4 a- IL)(TIAZOL-2-IL)METANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES COMO MODULADORES DEL RECEPTOR DE GLUCOCORTICOIDE.
