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Compounds and Methods for modulating Kinases and indications for the same.
专利权人:
PLEXXIKON; INC.
发明人:
IBRAHIM, PRABHA N.,ZHANG, CHAO,SPEVAK, WAYNE,ZHANG, JIAZHONG,WU, GUOXIAN,LIN, JACK,CHO, HANNA,NESPI, MARIKA,SHI, SONGYUAN,EWING, TODD,ZHANG, YING
申请号:
PE0018372013
公开号:
PE13602014A1
申请日:
2012.02.01
申请国别(地区):
PE
年份:
2014
代理人:
摘要:
Refers to a compound of formula I, or salts, solvates, hydrates, among others, where Y1 is selected from the group consisting of CN, halogen, - Oh, among others y2 is H, halogen, CN, c1-c6 alkylAmong others Q is selected from h, F, CL, among others Z is N (R4) (R5), C (r6) (R7) (R8), R4 and R5 are selected separately each of the group consisting of H, C1 - c6alquilo, among others.R6, R7, R8 are each separately h, c1-c6 alkyl, c6haloalcoxi C1, C3 c8cicloalquilo, among others.Preferred compounds are [2-fluoro-3 - (fenilosulfamoilamino) phenyl] - [5 - (2 - metoxipirimidin - 5 - il) - 1H pyrrolo [2,3-b] pyridin-3-yl] methanone,3 - [2-fluoro-3 - [methyl (phenyl) sulfamoyl] benzoyl] amino] - 5 - (2 - metoxipirimidin - 5 - il) - 1H pyrrolo [2,3-b] pyridine, among others.It also relates to a Pharmaceutical composition that is useful for treating diseases and conditions associated with Aberrant activity of Protein Kinases.SE REFIERE A UN COMPUESTO DE FORMULA I, O SALES, HIDRATOS, SOLVATOS, ENTRE OTROS, DONDE Y1 SE SELECCIONA DEL GRUPO QUE CONSISTE EN CN, HALOGENO, -OH, ENTRE OTROS Y2 ES H, HALOGENO, CN, C1-C6 ALQUILO, ENTRE OTROS Q ES SELECCIONADO DE H, F, CL, ENTRE OTROS Z ES -N(R4)(R5), -C(R6)(R7)(R8), DONDE R4 Y R5 SON SELECCIONADOS CADA UNO POR SEPARADO DEL GRUPO QUE CONSISTE EN H, C1-C6ALQUILO, ENTRE OTROS, R6, R7, R8 SON CADA UNO POR SEPARADO H, C1-C6 ALQUILO, C1-C6HALOALCOXI, C3-C8CICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS [2-FLUORO-3-(FENILOSULFAMOILAMINO)FENILO]-[5-(2-METOXIPIRIMIDIN-5-IL)-1H-PIRROLO[2,3-B]PIRIDIN-3-IL]METANONA, 3-[2-FLUORO-3-[[METIL(FENILO)SULFAMOIL]AMINO]BENZOIL]-5-(2-METOXIPIRIMIDIN-5-IL)-1H-PIRROLO[2,3-B]PIRIDINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA TRATAR ENFERMEDADES Y ESTADOS VINCULADOS CON LA ACTIVIDAD ABERRANTE DE LAS PROTEINAS QUINASAS.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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