Refers to compounds of 1,4-diazabicyclo [3.2.2] nonanos of formula (i) wherein R1 and R2 are each (C1 - C6 h, alkyl, aryl, alkyl) (C1 - C6) with aryl or substituted, R1 and R2 are combined with the carbon Atoms to which they are bound to form a Ring carbociclico of 5 or 6 members. Preferred compounds are: 5 - (1,4-diazabicyclo [3.2.2] NONAN - 4-yl) - 2-methyl - 7H - isoxazolo [2,3] pyrimidin-7-one 5 - (1,4-diazabicyclo [3.2.2] NONAN - 4-yl) - 2 - ethyl - 7H - isoxazolo [2,3] pyrimidin-7-one 5 - (1,4-diazabicyclo [3.2.2] NONAN - 4-yl) - 2 - Benzyl - 7H - isoxazolo [2,3] pyrimidin-7-one among others. It also relates to a Pharmaceutical composition.These compounds are modulators of neuronal nicotinic acetylcholine receptors are useful in the treatment of senile dementia, Alzheimers disease, Dementia with Lewy bodiesSE REFIERE A COMPUESTOS DERIVADOS DE 1,4-DIAZABICICLO[3.2.2]NONANOS DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H, ALQUILO(C1-C6), ARILO, ALQUILO(C1-C6) SUSTITUIDO CON ARILO, O R1 Y R2 SE COMBINAN CON LOS ATOMOS DE CARBONO A LOS QUE ESTAN UNIDOS PARA FORMAR UN ANILLO CARBOCICLICO DE 5 O 6 MIEMBROS. SON COMPUESTOS PREFERIDOS: 5-(1,4-DIAZABICICLO[3.2.2]NONAN-4-IL)-2-METIL-7H-ISOXAZOLO[2,3-a]PIRIMIDIN-7-ONA 5-(1,4-DIAZABICICLO[3.2.2]NONAN-4-IL)-2-ETIL-7H-ISOXAZOLO[2,3-a]PIRIMIDIN-7-ONA 5-(1,4-DIAZABICICLO[3.2.2]NONAN-4-IL)-2-BENCIL-7H-ISOXAZOLO[2,3-a]PIRIMIDIN-7-ONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES NICOTINICOS NEURONALES DE ACETILCOLINA SIENDO UTILES EN EL TRATAMIENTO DE DEMENCIA PRESENIL, ENFERMEDAD DE ALZHEIMER, DEMENCIA DE LOS CUERPOS DE LEWY
