您的位置: 首页 > 农业专利 > 详情页

Compounds 8 - (1,3-dihydro-isoindol-2-ilmeth) - 2,9-dihydro-1,2,7,9-tetraaza-fenalen-3-one and their compounds
专利权人:
EISAI INC.
发明人:
XU, WEIZHENG,ZHANG, JIE,WEI, LING,DELAHANTY, GREG
申请号:
PE2010000205
公开号:
PE20110993A1
申请日:
2010.04.05
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
A formula (I) tetramethylphenyl-3-ona compound,Among them, R is nr1r2, ariloxi is replaced by halogenated, alcoxi C1-C6, trifluoride iodine and other substances, or 1 to 7 heterogeneous substances selected from O, n or s, the substitutes are halogenated, oh, nitro, etc.; R1 is h, C1-C6 tar, alquenilo C2-C6, etc.; R2 is C1-C6 tar, phenyl, phenyl, phenyl, phenyl, phenyl, etc. The most popular compounds are: 8 - (4-hydroxy-pyridine-1-il) - 2,9-dihydro-1,2,7,9-tetranitro-phenyl-3-ona, 8 - (4-phenyl-1-methyl) - 2,9-dihydro-phenyl-1,2,7,9-tetranitro-phenyl-3-ona, 8-phenyl-2,9-dihydro-1,2,7,9-tetranitro-phenyl-phenyl-phenyl-phenyl-3,There are others These compounds inhibit the detection of the enzyme (ADP ribosa) and are useful in cancer chemotherapy.REFERIDA A UN COMPUESTO TETRAAZA-FENALEN-3-ONA DE FORMULA (I), DONDE R ES NR1R2, ARILOXI SUSTITUIDO CON HALO, ALCOXI C1-C6, TRIFLUOROMETILO, ENTRE OTROS O UN HETEROCICLO DE 1 A 7 HETEROATOMOS SELECCIONADOS DE O, N O S, OPCIONALMENTE SUSTITUIDO CON HALO, OH, NITRO, ENTRE OTROS; R1 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R2 ES ALQUILO C1-C6, FENILO, FENOXI, BENCILOXI, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 8-(4-HIDROXI-PIPERIDIN-1-IL)-2,9-DIHIDRO-1,2,7,9-TETRAAZA-FENALEN-3-ONA, 8-(4-BENCIL-PIPERIDIN-1-ILMETIL)-2,9-DIHIDRO-1,2,7,9-TETRAAZA-FENALEN-3-ONA, 8-FENOXIMETIL-2,9-DIHIDRO-1,2,7,9-TETRAAZA-FENALEN-3-ONA, ENTRE OTROS. DICHOS COMPUESTOS INHIBEN LA POLI(ADP-RIBOSA)POLIMERASA (PARP) Y SON UTILES EN LA QUIMIOSENSIBILIZACION DE TERAPIA CONTRA EL CANCER
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充

网站统计