Relates to compounds of formula (i), where a is - or or - CH2 - n is 0 OR 1 r1 is alkyl or haloalquilo C1 - C6 C1 - C6 R2 is H, cyano, among others R5 and R6 are heterociclilo, aryl, among others. Preferred compounds are: 6 - (3,5-dichlorophenyl) - 5 - methylspiro [chroman - 4,2\u00b4 imidazole] - 4 - Amine n - (4 - amino - 5 - methyl imidazole 4,2\u00b4 chromane - spiro [] - 6 - il) - 5 - Chloro - pyridine - 2 - carboxamide among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of the Enzyme cleavage of the beta site amyloid precursor protein (BACE), being useful for the treatment of the disease of Alzheimers disease, senile dementia, Hereditary Cerebral Hemorrhage, loss of Memory, among othersSe refiere a compuestos de formula (I), donde: A es -O- o -CH2- n es 0 o 1 R1 es alquilo C1-C6 o haloalquilo C1-C6 R2 es H, ciano, entre otros R5 y R6 son heterociclilo, arilo, entre otros. Son compuestos preferidos: 6-(3,5-diclorofenil)-5´-metilespiro[croman-4,2´-imidazol]-4´-amina N-(4´-amino-5´-metil-espiro[cromano-4,2´-imidazol]-6-il)-5-cloro-piridina-2-carboxamida entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son inhibidores de la enzima de escision de la proteina precursora amiloide de beta-sitio (BACE), siendo utiles para el tratamiento del mal del Alzheimer, demencia senil, hemorragia cerebral hereditaria, perdida de memoria, entre otros
