Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.本文中提供了多特異性(例如雙特異性)結合分子,其包含結合肌營養不良蛋白聚糖的細胞外部分的第一結合結構域和結合層黏連蛋白-2的第二結合結構域。本文中還提供了製造這種結合分子的方法以及這種結合分子用於治療和/或預防α-肌營養不良蛋白聚糖病的用途。