CEDARBAUM JESSE,MAO JOHN,MALIK FADY,WOLFF ANDREW A.
申请号：
IN200DEN2014
公开号：
IN200DEN2014A
申请日:
2014.01.09
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
Provided is a method for treating ALS in a subject comprising administering to the subject a therapeutically effective amount of riluzole and a therapeutically effective amount of CK 2017357. Also provided are methods of reducing the variability of riluzole exposure (e.g. Cmax and/or AUC24h) in a subject methods of reducing the variability of riluzole exposure (e.g. Cmax and/or AUC24h) between two or more subjects methods of decreasing the total daily dose of riluzole in a subject methods of increasing the half life of riluzole in a subject methods for decreasing the frequency of riluzole dosing in the subject and methods for reducing the incidence and/or severity of adverse events in a subject treated with riluzole.
