CYTOKINETICS, INC.;FADY MALIK;JESSE CEDARBAUM;JOHN MAO;ANDREW A. WOLFF
发明人:
ANDREW A. WOLFF,FADY MALIK,JESSE CEDARBAUM,JOHN MAO
申请号：
BR112014000742
公开号：
BR112014000742A2
申请日:
2012.07.12
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
Provided is a method for treating ALS in a subject, comprising administering to the subject a therapeutically effective amount of riluzole and a therapeutically effective amount of CK-2017357. Also provided are methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) in a subject, methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) between two or more subjects, methods of decreasing the total daily dose of riluzole in a subject, methods of increasing the half-life of riluzole in a subject, methods for decreasing the frequency of riluzole dosing in the subject, and methods for reducing the incidence and/or severity of adverse events in a subject treated with riluzole.
