WOLFF, ANDREW A.; INC.;MAO, JOHN;CEDARBAUM, JESSE;CYTOKINETICS, INC.;MALIK, FADY;CYTOKINETICS
发明人:
CEDARBAUM, JESSE,MAO, JOHN,MALIK, FADY,WOLFF, ANDREW A.
申请号：
EP12811325
公开号：
EP2731611A4
申请日:
2012.07.12
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Provided is a method for treating ALS in a subject, comprising administering to the subject a therapeutically effective amount of riluzole and a therapeutically effective amount of CK-2017357. Also provided are methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) in a subject, methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) between two or more subjects, methods of decreasing the total daily dose of riluzole in a subject, methods of increasing the half-life of riluzole in a subject, methods for decreasing the frequency of riluzole dosing in the subject, and methods for reducing the incidence and/or severity of adverse events in a subject treated with riluzole.
