JESSE CEDARBAUM,JOHN MAO,FADY MALIK,ANDREW A. WOLFF
申请号：
HK14110537.3
公开号：
HK1197178A
申请日:
2014.10.22
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
Provided is a method for treating ALS in a subject, comprising administering to the subject a therapeutically effective amount of riluzole and a therapeutically effective amount of CK-2017357. Also provided are methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) in a subject, methods of reducing the variability of riluzole exposure (e.g., Cmax and/or AUC24h) between two or more subjects, methods of decreasing the total daily dose of riluzole in a subject, methods of increasing the half-life of riluzole in a subject, methods for decreasing the frequency of riluzole dosing in the subject, and methods for reducing the incidence and/or severity of adverse events in a subject treated with riluzole.
