INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF

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专利权人:

THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人:

MATTHEW R. REDINBO,AADRA BHATT

申请号：

US16482998

公开号：

US20200010479A1

申请日:

2018.02.05

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Methods utilizing compounds and compositions are provided that comprise selective β-glucuronidase inhibitors. The methods can ameliorate the side effects of chemotherapeutic agents and can improve the efficacy of such agents, including irinotecan and non-steroidal anti-inflammatory drugs. The methods comprise administering the compounds in combination with agents or administering the compounds in a monotherapy for the treatment of cancer and gastrointestinal conditions.

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