PROBLEM TO BE SOLVED: To provide a lyophilized preparation of an ophthalmologic disease therapeutic agent containing a vascular endothelial growth factor (VEGF) inhibitor in a nanoparticle form.SOLUTION: The present invention provides lyophilized preparation of an ophthalmologic disease therapeutic agent containing a compound in a nanoparticle form, represented by formula (I) (R1 and R2 may be the same or different to denote a C1-C6 alkoxy group, R3 is a halogen atom, R4 and R5 may be the same or different to denote a hydrogen atom or the like, R6 and R7 may be the same or different to denote a C1-C4 alkyl group or the like) or a pharmaceutically acceptable salt thereof, or a hydrate or a solvate thereof.SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】ナノ粒子形態の血管内皮増殖因子（VEGF）阻害剤を含む眼科疾患治療剤の凍結乾燥製剤の提供。【解決手段】ナノ粒子形態の式(I)（Ｒ1およびＲ2は、同一または異なって、Ｃ１－Ｃ６アルコキシ基を表し、Ｒ3は、ハロゲン原子を表し、Ｒ4およびＲ5は、同一または異なって、水素原子等を表し、Ｒ6およびＲ7は、同一または異なって、Ｃ１－Ｃ４アルキル基等を表す）で表される化合物もしくはその薬学的に許容可能な塩、またはそれらの水和物もしくは溶媒和物を含む眼科疾患治療剤の凍結乾燥製剤。【選択図】なし
