SHAH, SYED M.,HASSAN, DANIEL,HASSAN, FRED,CORSINO, PATRICK
申请号：
CA3067822
公开号：
CA3067822A1
申请日:
2018.06.15
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A composition includes a pharmaceutical dosage form configured to dinsintegrate in saliva and maintain a pH of 4 or less within the saliva during the time the dosage form is dissolving therein. The dosage form includes a therapeutically effective amount of melatonin in a carrier matrix, a disintegrant, and a sufficient amount of acid to impart the pH to the saliva. The amount of disintegrant is sufficient to cause the dosage form to completely disintegrate in the saliva within ten minutes from contacting the saliva.
