Research & Business Foundation Sungkyunkwan University
发明人:
申请号：
EP16830880.7
公开号：
EP3329913A1
申请日:
2016.07.29
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to a composition for inhibiting the formation of a SNARE complex, containing myricetin derivatives, and can provide a composition for inhibiting the formation of a SNARE complex, in which myricetin derivatives, which have novel structures and are obtained by the acylation of myricetin, in addition to laricitrin, combretol, and syringetin, which is one of the derivatives of myricetin, are used as a SNARE targeting prodrug, since the myricetin derivatives have an activity of inhibiting the formation of a SNARE complex in vivo. According to research results, the myricetin derivatives are considered to exhibit an effect of being bioconverted into myricetin in a cell. The myricetin derivatives lost the dark color of conventional myricetin and properties thereof were changed such that the myricetin derivatives have properties of photostability and fat solubility. Therefore, since stable form myricetin derivatives are absorbed into a cell such that an activity, possessed by normal myricetin, of inhibiting the formation of a SNARE complex are exhibited, the present invention can exhibit an excellent function as a SNARE targeting prodrug, and as a composition for inhibiting the formation of a SNARE complex, containing the same.
