성균관대학교 산학협력단;RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
发明人:
KWEON, Dae Hyuk,권대혁,PARK, Joon Bum,박준범,JUNG, Young Hun,정영훈,CHUNG, Woo Jae,정우재,HEO, Pa Ul,허바울
申请号：
KRKR2016/008333
公开号：
WO2017/018847A1
申请日:
2016.07.29
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a composition for inhibiting the formation of a snare complex, containing myricetin derivatives, and can provide a composition for inhibiting the formation of a snare complex, in which myricetin derivatives, which have novel structures and are obtained by the acylation of myricetin, in addition to laricitrin, combretol, and syringetin, which is one of the derivatives of myricetin, are used as a SNARE targeting prodrug, since the myricetin derivatives have an activity of inhibiting the formation of a snare complex in vivo. According to research results, the myricetin derivatives are considered to exhibit an effect of being bioconverted into myricetin in a cell. The myricetin derivatives lost the dark color of conventional myricetin and properties thereof were changed such that the myricetin derivatives have properties of photostability and fat solubility. Therefore, since stable form myricetin derivatives are absorbed into a cell such that an activity, possessed by normal myricetin, of inhibiting the formation of a SNARE complex are exhibited, the present invention can exhibit an excellent function as a material usable as a SNARE targeting prodrug, and as a composition for inhibiting the formation of a snare complex, containing the same.La présente invention concerne une composition pour inhiber la formation d'un complexe SNARE, contenant des dérivés de myricétine, et peut fournir une composition pour inhiber la formation d'un complexe SNARE, dans laquelle les dérivés de myricétine, qui ont des nouvelles structures et sont obtenus par l'acylation de myricétine, en plus de la laricitrine, du combrétol, et de syringétine, qui est l'un des dérivés de la myricétine, sont utilisés en tant que promédicament ciblant SNARE, étant donné que les dérivés de myricétine ont une activité d'inhibition de la formation du complexe SNARE in vivo. Selon les résultats de recherche, il est estimé que les dérivés de myricétine présentent un effet de biocon
