RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
发明人:
Dae Hyuk KWEON,Joon Bum PARK,Young Hun JUNG,Woo Jae CHUNG,Pa Ul HEO
申请号：
US15748500
公开号：
US20180222878A1
申请日:
2016.07.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a composition for inhibiting the formation of a SNARE complex, containing myricetin derivatives, and having novel structures and obtained by the acylation of myricetin, laricitrin, combretol, or syringetin. The myricetin derivatives are considered to exhibit an effect of being bioconverted into myricetin in a cell. The myricetin derivatives lost the dark color of conventional myricetin and properties thereof were changed such that the myricetin derivatives have properties of photostability and fat solubility. Therefore, since stable form myricetin derivatives are absorbed into a cell such that an activity, possessed by normal myricetin, of inhibiting the formation of a SNARE complex are exhibited, the present invention can exhibit an excellent function as a SNARE targeting prodrug, and as a composition for inhibiting the formation of a SNARE complex, containing the same.
