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Benzofuran and Benzothiophosphorus Derivatives as PGE2 Receptor Modulators
专利权人:
IDORSIA PHARMACEUTICALS LTD.
发明人:
申请号:
ARP180101312
公开号:
AR111807A1
申请日:
2018.05.17
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
Requirement 1: A formula (1) compound for cancer treatment, in which the treatment of cancer is modulated by the immune response, including the recovery of the tumor's immune system; The compound can be used in combination with one or more chemotherapeutics and/or radiotherapy and/or directional therapy; in formula compound (1): formula fragment (2), it is replaced by R 2.R2 represents hydrogen, C83218331838324 tar, halogen or cyanide, and (R1) 8345 can be used instead.(R1) C8345; stands for 1, 2 or 3 alternatives, in which R1 alternatives should be independently from C83218C83331C833183238Alcoy, CCs-3183331C832318FLUOAL Quilo, C83218331833238FLUOAL Loxic, or Ciano; X stands for S-O; R3 stands for C8323232323233; A. Methyl or trifluoroiodine; r8308; 74919 and R8308; 74955 stand for hydrogen, methyl or R8308; 7491 and R8308; 74919 and R8308; 7495 and the carbon atoms attached to them represent a bicycle-1, 1-diilo group; R8309; 7491 and R8309; 74959 stand for hydrogen, methyl or R83747491y independently; R8309, 74959, and the associated carbon atoms represent a cyclopropane-1,1-diacyl group.AR1 represents phenyl, or a heteromorphic form of 5 or 6 members, of which 5 or 6 members are phenyl or heteromorphic independent.D.Di-o Trisustitute, in which C832183.31832626 tar, C832183.318324alcoy, C83218331238FLUQUIL, C8321218331833238FLU, C832123238FLU hydrogen XI, C8321833183323238FLO were selected independently. C.C8323833183626 cycloquilo, in which C832383318332626 cycloquilo was not replaced or MONO-substituted by aminobenzene; C832483318326cycloquilo contained epoxy atoms, and C832483318326cycloquilo contained epoxy atoms was not replaced or replaced. E. On hydroxi; C83238331326 Ccyclo-oxi; hydroxi; X1-CO-Ro1;X1 stands for direct link, C8321832323 lessor, -O-C832183318323 lessor, **,- NH-C832183.31832323 tar-*;- S-CH832222-**-CF8322-,-CH=CH---Ch...-NH-CO-**- I...O C83238331; 8325 cycloquileno, in which asterisks are associated with the CO-RO1 group;Y Ro1 stands for --
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