SUET CHUNG YEUNG,JENNIFER ANNE TREIBERG,GARY PHILLIPS,BARTON W. PHILLIPS,STEPHANE PERREAULT,LEENA PATEL,JOSHUA KAPLAN,JERRY EVARTS
申请号：
ARP150101856
公开号：
AR100806A1
申请日:
2015.06.11
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
These compounds inhibit the activity of phosphoric acid-3-quinine (pl3k) and contribute to the treatment of conditions facilitated by one or more pl3k variants. The present application also provides pharmaceutical ingredients including a formula compound (1).O salts, isomers, Dow agents or mixtures acceptable to the same agent, and methods of treating one or more pl3k isomers with these compounds and components.a. X, y, Z are independent of C (R) or n. at least one X, y, Z in C (R) or n is C (R)；N is 0, 1, 2, 3, or 4； m is 0 or 1； a is a simple link or C (o)；Each RR is independent of hydrogen, halogen, alternative asphalt, alternative halide and alternative cyclomethane； each R1 is independent of halogen, cyanogen and one to six alternative carbon tar. 1-6 alternative carbon atoms, 3-8 alternative carbon atoms, epoxy of alternative carbon atoms, and sulfur alternative to replacement； each square kilometer is independent of halogenated, 1-6 alternative carbon atoms of tar, One to six substituted halidesR3 is hydrogen, tar with one to six alternative carbon atoms, epoxy compound with three to eight alternative carbon atoms, or arilo with six to ten alternative carbon atoms； r83088 is a heterogeneous compound with six to twelve members； Among them, there are at least two heteroatoms. In the heteroatom, each heteroatom is independent of the selection of N, O, O and s. The heteroatom is replaced by one, two or three members independent of halogenation and cyanogen,There are 1-6 tar with selective substitution of carbon atom, 2-6 tar with selective substitution of carbon atom； r83099 and r83099 are 1-6 hydrogen or tar with selective substitution of carbon atom； r83099 and R3, together with the atoms attached to them, can optionally form 4-8 heterocyclic rings. 1. A member； or a salt, an isomer, or a mixture thereof, which is pharmaceutically acceptable.Los compuestos son inhibidores de las actividades de la fosfatidilinositol 3-quinasa (Pl3K) y son útiles para el tratamie
