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Isxazol carboxamida compounds and their applications
专利权人:
NOVARTIS AG
发明人:
BECKWITH, ROHAN ERIC JOHN,JIANG, HUA,WANG, CE
申请号:
ARP180100694
公开号:
AR111252A1
申请日:
2018.03.23
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
Claim 1: A formula compound (1),Or a drug-acceptable saltCharacteristic: R1 is selected from phenyl.Temptation and anger1. Each alternative is replaced by 1-2F.L is a selective replacement of C8331832626, which is independent of C8321833832626 and halogen 1-4 substitutes.There?Optional1. Substitute C8321C8331832626 tar with carbon atom and form a three-ring fingernail ring with it.R2 and R 3, together with their associated nitrogen atoms, form different cycles of four to ten members, consisting of carbon atoms and 1-3 heteroatoms selected independently from N and O.Alternative 1-4 R83088 was replaced;Each R830808 is selected independently from C8321358331832626 asphalt.Cyoquilo C83238C83318328;Halogen.(Lessor C832031-83323) - CN,Halogenated tar C832183531832626,Haloalcoxyl C83218C833316A1;(c) C832020OJ 8331832626) - Or 8309;It is life.NH (C = O) R8309;NH (C = O) Or8311;NH (C = O) N (R83099) 83222;(c = o) n (R831111n) 8322;(c = o) R8309;(c = o) o (rent No. C832131)(c = o) o (cycloquilo C83238331;S(= O) 8322; R83099;S(= O) 8322; (R831111) 8322;NHS (= O) 8322; R83099;A. Selectively substituting phenyl with 1-3 R8310A and 5-A-6 heterogenous members, including carbon atoms and 1-3 heterogenous atoms independently selected from N.O and alternative S were replaced by 1-3 R8310;Each r83099 is selected independently from H.1. C83218331-832626 and C83238331838328;Each r83100E was selected independently from C8321C8331832626 matrix.Cyoquilo C83238C83318328;Halogen.CN,Halogenated tar C832183531832626,Haloalcoxyl C83218C833316A1;Or83099,N (R830909) 832222;NH (C = O) R8309;(c = o) n (R83099) 8322;(c = o) R8309;(c = o) Or83099;S (= O) 8322; R83099 and S (= O) 8322; n (R830909) 8322;Each r8311th is selected independently from H.1. C83218331 and 832626 leased land;Cyoquilo C832388328 was selectively replaced by 1-2 Or83099.(c) C832031-8323Y-CN Y (Acquileno C8320833183323) - Or83099;Reivindicación 1: Un compuesto de la fórmula (1), o una sal farmacéuticamente aceptable del mismo, car
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