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3-phenyl-4 (3H) - substituted onas and its application
专利权人:
BAYER AKTIENGESELLSCHAFT;BAYER PHARMA AKTIENGESELLSCHAFT
发明人:
DR. BOULTADAKIS ARAPINIS, MELISSA,DR. ZORN, LUDWIG,DR. THEDE, KAI,DR. GIESE, ANJA,DR. LANG, DIETER,DR. BENDER, ECKHARD,DR. GAUGAZ, FABIENNE ZDENKA,DR. DIETZ, LISA,DR. HAHN, MICHAEL,DR. BORISSOFF, JULI
申请号:
ARP180102771
公开号:
AR112840A1
申请日:
2018.09.27
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
1. Claim 1: compound (1) of general formula,The characteristic is that R1 represents hydrogen, methyl or halogen atoms; R2 represents a phenyl or heteromorphic group of 5 to 10 members, in which any phenyl group and any heteromorphic group of 5 to 10 members can be replaced by one, two or three groups in the same or different ways. a. From the halogen atom, tar - c83331832421;Amino, mono - rental mino-c832131;Di-let-c83218833124;1.Hidroxi,Ciano,alcoxicarbonilo-C83218331S 8324;e. Alcox-c833124218 and trifluomethoxi, in which the hydrocarbyl-c833183832431 can replace hydrogen Xi or at most five fluorine atoms; R3 represents hydrogen, methyl or halogen atoms; r8308 represents a group selected from hydrogen, hydrocarbyl-c8331832424 and cyclopentane-c833233183268383;a. On the same or different basis, one or two groups selected from the hydroxyl group, c8321c83331832424, are selected to replace the asphalt;e. Free acrylonitrile, up to 5 fluorine atoms can be selected; r83099 represents a group selected from a hydrogen and tar atom - c832183318324;a. The condition is that the ionosphere of r83088 and r83099 has at least one different from hydrogen, or r83088 and r83099, plus the carbon atoms connected with them, forming a carbohydrate of 3 to 6 members or a different cycle of 4 to 6 members, in which different cycles of 4 to 6 members can be replaced by one or two tar groups - c832183318331832483; a. No more than 4 fluorine atoms can be selected. Among these atoms, the tar-c8333183248c can be optionally replaced by no more than 5 fluorine atoms. Among these atoms, the carbon thyroid of 4 to 6 members can be optionally replaced by one or two tar-c83318324y groups, and optionally no more than 4 fluorine atoms;There, the tar-c83217c831832424 can be selectively replaced with up to five fluorine atoms; r8310 represents - 35; - nr1,1,a. A pagan group of five or six members, di-taxi-c8332131; or alcoxicarbornilamino-c83318324;Among them, ° 35 represents the connection point of ca
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